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Product Name
Recombinant ENPP5 protein (His tag)
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Description
Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) Fragment (aa 25-401) - A highly purified, stable protein fragment ideal for investigating NAD hydrolysis mechanisms and neuronal communication pathways. This 377-amino acid construct was computationally optimized for superior solubility and structural integrity, making it perfect for biochemical assays and functional studies.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5) is a human enzyme that specifically hydrolyzes NAD while lacking activity toward nucleotide di- and triphosphates. Unlike some family members, ENPP5 does not exhibit lysophospholipase D activity. The protein is implicated in neuronal cell communication processes, suggesting important roles in nervous system function. ENPP5 displays dual subcellular localization, existing both as a secreted protein and as a single-pass membrane protein, indicating potential functions in both extracellular signaling and membrane-associated processes. The full-length protein's specific NAD-hydrolyzing capability distinguishes it from other phosphodiesterase family members and highlights its unique biological significance.
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Protein name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5
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Uniprot ID
Q9UJA9
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Gene Name
ENPP5
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 25-401 aa (Q9UJA9) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 45.33 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 46 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"