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Product Name
Recombinant ENH3 protein (His tag)
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Description
This recombinant protein product features a stable and soluble 142-amino acid fragment (residues 75-216) of the HERV-H_2q24.1 provirus ancestral Env polyprotein (Env protein HERV-H/p59). Derived from human endogenous retroviral elements, this fragment is ideal for structural studies, biochemical assays, and functional investigations of envelope protein domains.
The full-length HERV-H_2q24.1 Env polyprotein is a human endogenous retroviral envelope protein that originally functioned in receptor recognition and membrane fusion during viral infection. While it has lost its ancestral fusogenic properties through evolution, its Surface protein (SU) subunit mediates receptor recognition, and the Transmembrane protein (TM) anchors the envelope complex to membranes via a transmembrane domain. This protein is localized to virions and the cell membrane, representing a Single-pass membrane protein. Endogenous envelope proteins like HERV-H/p59 provide valuable insights into retroviral evolution and potential physiological roles in humans.
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Protein name
HERV-H_2q24.1 provirus ancestral Env polyprotein
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Uniprot ID
Q9N2J8
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 75-216 aa (Q9N2J8) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 17.27 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 17 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"