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  • Endomorphin peptide

Endomorphin peptide

Not For Human Use, Lab Use Only.

Cat.#: 317046

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Product Information

  • Product Name
    Endomorphin peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    YPWF-NH2
  • Sequence
    Tyr-Pro-Trp-Phe-NH2
  • Length (aa)
    4
  • Peptide Purity (HPLC)
    96.2%
  • Molecular Formula
    C34H38N6O5
  • Molecular Weight
    610.7
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Endomorphin belongs to Opioid. The peptide has the modification: 4 Phe amide. The endogenous peptides ligands for μ opioid receptor (MOR), endomorphin 1 (Tyr1-Pro2-Trp3-Phe4-NH2, EM1) and endomorphin2 (Tyr1-Pro2-Phe3-Phe4-NH2, EM2) were discovered in 1997 by Zadina et al.[1].

    EMs exhibit the highest affinity to the MOR and extraordinarily high selectivity relative to the δ and κ opioid receptor systems of all known opioid substances.[2][3]

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • 1.Champion HC, Zadina JE, Kastin AJ, Hackler L, Ge LJ, Kadowitz PJ. Endomorphin 1 and 2, endogenous ligands for the mu-opioid receptor, decrease cardiac output, and total peripheral resistance in the rat. Peptides. 1997;18(9):1393-7.
    • 2. Chu XP, Xu NS, Li P, Wang JQ. Endomorphin-1 and endomorphin-2, endogenous ligands for the mu-opioid receptor, inhibit electrical activity of rat rostral ventrolateral medulla neurons in vitro. Neuroscience. 1999;93(2):681-6.
    • 3. Yu Y, Shao X, Wang CL, Liu HM, Cui Y, Fan YZ, Liu J, Wang R In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: evidence for the important role of proper spatial disposition of the third aromatic ring Peptides 2007 Apr;28(4):859-70
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"