Recombinant EMC8 protein (His tag)

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Recombinant Human EMC8 (ER Membrane Protein Complex Subunit 8) Fragment (aa 1-210) is a high-purity protein designed for studying the MPN domain's role in membrane protein insertion. This fragment provides a targeted tool to investigate endoplasmic reticulum-associated processes and topology regulation of multi-pass membrane proteins.

EMC8, also known as FAM158B, is a component of the endoplasmic reticulum membrane protein complex (EMC) that facilitates the energy-independent insertion of newly synthesized membrane proteins into ER membranes. It preferentially accommodates transmembrane domains with weak hydrophobicity or destabilizing features and is involved in both cotranslational insertion of multi-pass membrane proteins and post-translational insertion of tail-anchored proteins. By ensuring proper topology of proteins like G protein-coupled receptors, EMC8 indirectly influences numerous cellular processes. The protein localizes to the endoplasmic reticulum membrane as a peripheral membrane protein on the cytoplasmic side, underscoring its direct role in membrane biogenesis and protein sorting.

1-210