Recombinant EIF3D protein (His tag)

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Recombinant Human EIF3D (eIF3d) Fragment (aa 131-548) is a high-quality protein product designed for structural and biochemical studies. This 418-amino acid fragment represents a stable and soluble region of the eukaryotic translation initiation factor 3 subunit D, a key mRNA cap-binding component involved in specialized translation initiation processes.

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is an essential mRNA cap-binding component of the eIF-3 complex, which plays a critical role in multiple steps of protein synthesis initiation. The full-length protein facilitates the formation of the 43S pre-initiation complex, stimulates mRNA recruitment and scanning for AUG recognition, and is required for ribosomal complex disassembly and recycling. EIF3D specifically recognizes and binds the 7-methylguanosine cap of a specialized repertoire of mRNAs involved in cell proliferation, differentiation, and apoptosis, exerting either translational activation or repression. Additionally, during FCV infection, it participates in ribosomal termination-reinitiation events. The protein is localized in the cytoplasm, where it performs its essential functions in translation regulation.