Recombinant EDA protein (His tag)

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Recombinant Human Ectodysplasin-A (EDA) Fragment (aa 184-391) is a high-purity protein preparation encompassing the complete TNF homology domain (THD). This fragment serves as an essential research tool for investigating epithelial-mesenchymal signaling, ectodermal organ morphogenesis, and receptor-ligand interactions with EDAR and EDA2R, providing targeted insights into the functional mechanisms of this critical cytokine.

Ectodysplasin-A is a cytokine that plays a fundamental role in epithelial-mesenchymal signaling during the morphogenesis of ectodermal organs. It functions as a ligand that activates death-domain containing receptors EDAR and EDA2R, with different isoforms exhibiting receptor specificity—isoform 1 binds exclusively to EDAR while isoform 3 binds exclusively to EDA2R. The full-length protein exists in both membrane-bound and secreted forms, with the membrane form being a single-pass type II membrane protein. EDA's involvement in cell adhesion processes further underscores its importance in developmental biology and tissue formation. Mutations in the EDA gene are associated with ectodermal dysplasia disorders, highlighting its clinical significance in human development and disease.