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Product Name
Recombinant DVL2 protein (His tag)
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Description
Recombinant Human DVL-2 (Dishevelled-2) Fragment (aa 264-385) is a high-purity protein designed for studying the PDZ domain's role in Wnt signaling pathways. This fragment serves as an essential tool for investigating domain-specific interactions and functions in both canonical and non-canonical Wnt signaling mechanisms.
The full-length Segment polarity protein dishevelled homolog DVL-2 (DVL2) is a key mediator in Wnt signal transduction pathways, functioning in both canonical and non-canonical Wnt signaling. It binds to the cytoplasmic C-terminus of frizzled receptors and facilitates downstream signal propagation while promoting internalization and degradation of frizzled proteins upon Wnt activation. DVL-2 localizes primarily to the cell membrane as a peripheral membrane protein on the cytoplasmic side, but also resides in the cytosol, cytoplasmic vesicles, and can translocate to the nucleus through interactions with FOXK1/FOXK2. This recombinant fragment spanning residues 264-385 specifically contains the PDZ domain (267-339), enabling focused research on this critical functional domain's contributions to DVL-2's signaling capabilities.
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Protein name
Segment polarity protein dishevelled homolog DVL-2
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Uniprot ID
O14641
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Gene Name
DVL2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 264-385 aa (O14641) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 14.89 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"