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Product Name
Recombinant DTX3 protein (His tag)
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Description
Recombinant Probable E3 ubiquitin-protein ligase DTX3 (fragment 138-347) is a high-quality protein fragment derived from human DTX3, designed for structural and biochemical studies. This 210-amino acid fragment offers a stable and soluble unit ideal for investigating the ubiquitin ligase activity and regulatory functions of the full-length protein.
The full-length Probable E3 ubiquitin-protein ligase DTX3, encoded by the DTX3 gene in Homo sapiens, functions as a regulator of Notch signaling—a critical pathway involved in cell-cell communication and cell-fate determination. It may act as both a positive and negative regulator of Notch depending on developmental and cellular contexts, and exhibits ubiquitin ligase activity in vitro, suggesting a role in modulating the Notch pathway through ubiquitination. The protein is localized in the cytoplasm, where it likely participates in key regulatory processes.
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Protein name
Probable E3 ubiquitin-protein ligase DTX3
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Uniprot ID
Q8N9I9
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Gene Name
DTX3; RNF154
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 138-347 aa (Q8N9I9) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 24.96 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 25 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"