Recombinant DRB4 protein (His tag)

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Recombinant HLA-DRB4 (30-227) Fragment: A high-purity, functional protein fragment encompassing the Ig-like C1-type domain (residues 126-216) of the HLA class II histocompatibility antigen, DR beta 4 chain. This product is ideal for studying peptide binding, antigen presentation, and T-cell recognition mechanisms in immunological research.

The full-length HLA-DRB4 protein, encoded by the HLA-DRB4 gene in Homo sapiens, is a key component of MHC class II molecules. It functions by binding peptides derived from endocytosed antigens in antigen-presenting cells (APCs) and presenting them on the cell surface for recognition by CD4+ T-cells. This process is critical for initiating adaptive immune responses against exogenous pathogens. The protein transits through multiple intracellular compartments—including the endoplasmic reticulum, Golgi apparatus, endosomes, and lysosomes—before localizing to the cell membrane as part of the MHC class II-peptide complex. The fragment provided (residues 30-227) includes the essential Ig-like C1-type domain, enabling focused investigation into structural and functional aspects of antigen binding and immune regulation.