Recombinant DR9C7 protein (His tag)

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• Material Safety Data Sheets (MSDS)

Recombinant Human SDR9C7 (Short-chain dehydrogenase/reductase family 9C member 7) fragment (amino acids 1-313) is a high-purity protein designed for structural and functional studies. This fragment encompasses the full-length protein domain, optimized for stability and solubility, enabling researchers to investigate its enzymatic activity in epidermal barrier formation and lipid metabolism.

SDR9C7 is a cytoplasmic enzyme critical for establishing the epidermal permeability barrier in humans. It catalyzes the NAD+-dependent dehydrogenation of omega-O-acylceramides, specifically converting linoleate esters to 13-ketone derivatives, which are essential for covalent binding of ceramides to proteins in the skin. This process ensures proper skin integrity and hydration. While SDR9C7 exhibits weak activity in converting all-trans-retinal to all-trans-retinol, it lacks significant steroid dehydrogenase function. The protein localizes to the cytoplasm with a granular distribution, highlighting its role in intracellular lipid modification pathways relevant to dermatological and metabolic research.