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Product Name
Recombinant DOCK8 protein (His tag)
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Description
Our recombinant human DOCK8 protein fragment (residues 464-859) offers a high-purity, functional tool for studying the C2 DOCK-type guanine nucleotide exchange factor domain. This product enables focused research on CDC42 activation mechanisms in immune cell migration and signaling pathways.
Dedicator of cytokinesis protein 8 (DOCK8) functions as a guanine nucleotide exchange factor that specifically activates the small GTPase CDC42 by exchanging GDP for GTP. This protein plays critical roles in immune responses, including interstitial dendritic cell migration, CD4+ T-cell chemotaxis, and NK cell cytotoxicity through microtubule-organizing center polarization. DOCK8 localizes to the cytoplasm and translocates to the plasma membrane and lamellipodium membrane upon chemokine stimulation, where it co-localizes with CDC42 at immunological synapses. The provided fragment (464-859) contains the essential C2 DOCK-type domain, making it ideal for investigating domain-specific functions in CDC42-mediated signaling pathways.
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Protein name
Dedicator of cytokinesis protein 8
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Uniprot ID
Q8NF50
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Gene Name
DOCK8
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 464-859 aa (Q8NF50) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 46.85 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 47 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"