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Product Name
Recombinant DLG4 protein (His tag)
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Description
Recombinant Human Disks large homolog 4 (PSD-95) Fragment (aa 309-724) is a high-purity protein designed for studying synaptic scaffolding mechanisms. This fragment encompasses the critical PDZ 3, SH3, and Guanylate kinase-like domains, making it an ideal tool for investigating protein-protein interactions and synaptic plasticity in neurological research.
Disks large homolog 4 (DLG4), also known as PSD-95, is a key postsynaptic scaffolding protein essential for synaptogenesis and synaptic plasticity. It functions as a platform for clustering crucial synaptic proteins, interacting with NMDA receptor subunits and potassium channels to regulate synaptic signaling. The protein localizes primarily to the postsynaptic density in neuronal membranes and plays a role in stabilizing neurotransmitter receptors and modulating synaptic strength. Its involvement in synaptic organization makes it a fundamental target for neuroscience and neuropharmacology studies.
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Protein name
Disks large homolog 4
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Uniprot ID
P78352
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Gene Name
DLG4; PSD95
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 309-724 aa (P78352) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 48.90 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 53 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"