Mouse DKK3 (His Tag) recombinant protein
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Dickkopf-related protein 3
Protein short names
DICKKOPF3; AW061014; C87148; RIG; REIC; DICKKOPF 3; HDKK 3; HDKK3; DKK-3; DKK3
A DNA sequence encoding the extracellular domain (Met 1-Ile 349) of mouse DKK3 (NP_056629.1) precursor was expressed with a C-terminal polyhistidine tag.
The secreted recombinant mouse DKK3 consists of 338 amino acids and has a calculated molecular mass of 38 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 65 kDa protein in SDS-PAGE under reducing conditions.
> 97 % as determined by SDS-PAGE
Mouse Dkk-3 / DKK3 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"