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Product Name
Recombinant DEDD protein (His tag)
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Description
Recombinant Human Death Effector Domain-containing Protein (DEDPro1) Fragment (1-106) is a high-purity protein encompassing the full DED domain, designed for studying domain-specific functions in apoptosis regulation and protein scaffolding.
The full-length Death Effector Domain-containing Protein (DEDD) serves as a scaffold protein that directs CASP3 to specific substrates, facilitating their ordered degradation during apoptosis. It regulates intermediate filament degradation and may mediate CASP3 cleavage of KRT18. Additionally, it plays a role in nuclear transcription machinery, potentially regulating GTF3C3 activity and inhibiting DNA transcription in vitro. Subcellularly, it localizes to the cytoplasm and nucleolus, translocating to nuclear nucleoli during CD95-mediated apoptosis. Following apoptosis induction, ubiquitinated forms colocalize with KRT8/KRT18 intermediate filaments in epithelial cells, underscoring its role in cytoskeletal reorganization during cell death.
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Protein name
Death effector domain-containing protein
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Uniprot ID
O75618
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Gene Name
DEDD; DEDPRO1; DEFT
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-106 aa (O75618) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 14.27 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"