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Product Name
Recombinant DCXR protein (His tag)
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Description
Recombinant Human L-xylulose Reductase (XR) Fragment (1-244) is a high-purity protein designed for structural and biochemical studies. This stable, soluble fragment retains key functional domains, enabling research into its role in glucose metabolism and cellular osmoregulation.
L-xylulose reductase (XR), encoded by the DCXR gene, catalyzes the NADPH-dependent reduction of various sugars and α-dicarbonyl compounds, including L-xylulose. It plays a critical role in the uronate cycle of glucose metabolism and contributes to water absorption and osmoregulation in renal tubules by producing the osmolyte xylitol, thereby mitigating osmotic stress. The protein is localized to membranes as a peripheral membrane protein, likely interacting with phosphatidylinositol for membrane recruitment.
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Protein name
L-xylulose reductase
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Uniprot ID
Q7Z4W1
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Gene Name
DCXR; SDR20C1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-244 aa (Q7Z4W1) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 27.57 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 28 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"