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Product Name
Recombinant DCX protein (His tag)
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Description
Recombinant Neuronal Migration Protein Doublecortin (DCX) Fragment (aa 42-147) – a high-purity, functional fragment encompassing the complete Doublecortin 1 domain, designed for targeted studies of neuronal development, microtubule association, and cortical lamination mechanisms.
Doublecortin (DCX), encoded by the DCX gene in humans, is a microtubule-associated protein essential for neuronal dispersion and cortex lamination during cerebral cortex development. It functions in the initial steps of neuronal migration, potentially by competing with DCLK1 for target protein binding and participating in calcium-dependent signal transduction pathways. DCX may collaborate with PAFAH1B1/LIS-1 in overlapping signaling pathways that promote neuronal migration. Subcellularly, it localizes to the cytoplasm and neuronal projections, particularly at neurite tips, underscoring its role in neurite extension and neuronal interaction. The provided fragment (aa 42-147) includes the full Doublecortin 1 domain (aa 53-139), enabling focused investigation into domain-specific functions in neurodevelopmental processes.
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Protein name
Neuronal migration protein doublecortin
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Uniprot ID
O43602
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Gene Name
DCX; DBCN; LISX
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 42-147 aa (O43602) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 13.89 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"