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Product Name
Recombinant DCC1 protein (His tag)
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Description
Recombinant Sister Chromatid Cohesion Protein DCC1 (DSCC1) Fragment (1-393 aa) is a high-quality, stable protein designed for structural and biochemical studies. This fragment, derived from human DSCC1, represents a soluble and functional unit ideal for investigating DNA replication fork dynamics and sister chromatid cohesion mechanisms.
The full-length Sister Chromatid Cohesion Protein DCC1, encoded by the DSCC1 gene in Homo sapiens, plays a critical role in DNA replication and chromosome segregation. It functions by loading PCNA onto primed templates, thereby regulating the velocity, spacing, and restart activity of replication forks. Additionally, it may couple DNA replication to sister chromatid cohesion through the regulation of acetylation of the cohesin subunit SMC3. The protein is localized to the nucleus, where it contributes to genomic stability and accurate cell division, as supported by studies (PubMed:12766176, PubMed:19907496).
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Protein name
Sister chromatid cohesion protein DCC1
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Uniprot ID
Q9BVC3
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Gene Name
DSCC1; DCC1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-393 aa (Q9BVC3) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 46.48 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 51 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"