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Product Name
Human CRTAM (His Tag) recombinant protein
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Description
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
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Protein name
Cytotoxic and regulatory T-cell molecule
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Protein short names
CD355; CRTAM; MGC141606; MGC141607
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Uniprot ID
O95727
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Gene Name
CRTAM
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CRTAM (NP_062550.2) extracellular domain (Met 1-Ser 286) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CRTAM consists of 280 amino acids and predictes a molecular mass of 31.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCRTAM is approximately 50-60 kDa due to glycosylation.
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Purity
> 94 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized human CADM1 at 2 μg/ml (100 μl/well) can bind biotinylated human CRTAM with a linear range of 12.5-400 ng/ml.
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Validations
Human CRTAM Protein (His Tag) SDS-PAGE
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