Cynomolgus CD25/IL2RA (His Tag) recombinant protein

Cat.#: 503622

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Product Information

  • Product Name
    Cynomolgus CD25/IL2RA (His Tag) recombinant protein
  • Documents
  • Description
    CD25 (alpha-chain of IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling. The IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes (T1D). Cancer growth and development is associated with the stimulation of the innate immune system, including enhanced interleukin 2 receptor (IL-2R) expression in immune cells and its shedding into the circulation in a soluble form of sIL-2Ralpha. In most haematological malignancies, including different types of leukaemias and lymphomas, sIL-2Ralpha has been found to be released directly from the surface of neoplastic cells thus reflecting the tumour bulk, turnover and activity. Several studies have proved that not only lymphoid cancer cells, but also some non-lymphoid cancer cells, express IL-2R on their surface. They include malignant melanoma and carcinomas of the kidney, head and neck, oesophagus and lung. Thus, sIL-2Ralpha is elevated in most proliferative disturbances of the hematopoietic system and in many solid tumors.
  • Protein name
    Interleukin 2 receptor alpha
  • Protein short names
    TCGFR; P55; CD25; LY-43; MGC130561; IL2R; IL2RA; IDDM10; RP11-536K7.1
  • Uniprot ID
    H6WS54
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the cynomolgus IL2RA (H6WS54) (Met1-Arg213) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Cynomolgus
  • Molecular weight
    The recombinant cynomolgus IL2RA comprises 203 amino acids and has a calculated molecular mass of 23.1 KDa. The apparent molecular mass of it is approximately 43 KDa respectively in SDS-PAGE.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Cynomolgus IL2RA Protein (His Tag) SDS-PAGE

    Cynomolgus IL2RA Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"