Recombinant CUL7 protein (His tag)

• DataSheet
• COA (Batch NP456601)
• Material Safety Data Sheets (MSDS)

Recombinant Human Cullin-7 (CUL-7) Fragment (aa 621-1101) is a high-purity protein designed for studying the specific functions of the DOC domain. This fragment provides an essential tool for researchers investigating ubiquitination pathways, microtubule dynamics, and protein degradation mechanisms.

Cullin-7 (CUL-7) is a core component of the 3M and Cul7-RING(FBXW8) complexes that mediate ubiquitination and subsequent proteasomal degradation of target proteins. It plays critical roles in regulating microtubule dynamics, maintaining genome integrity, and controlling processes including Golgi morphogenesis, trophoblast cell epithelial-mesenchymal transition, and placental development. The protein localizes to the cytoplasm, centrosome, perinuclear region, and Golgi apparatus, with specific localization patterns mediated by interacting partners. The provided fragment (amino acids 621-1101) encompasses the DOC domain, enabling focused investigation of domain-specific functions within these complex biolog

MSKIKLQRLV EGYGPAGKIL LDLEQALSSE GTQENKVKPL LLQLQRQPQP FLALMQSLDT PETNRTLHLT VLRILKQLVD
FPEALLLPWH EAVDACMACL RSPNTDREVL QELIFFLHRL TSVSRDYAVV LNQLGARDAI SKALEKHLGK LELAQELRDM
VFKCEKHAHL YRKLITNILG GCIQMVLGQI EDHRRTHQPI NIPFFDVFLR YLCQGSSVEV KEDKCWEKVE VSSNPHRASK
LTDHNPKTYW ESNGSAGSHY ITLHMRRGIL IRQLTLLVAS EDSSYMPARV VVCGGDSTSS LHTELNSVNV MPSASRVILL
ENLTRFWPII QIRIKRCQQG GIDTRIRGLE ILGPKPTFWP VFREQLCRHT RLFYMVRAQA WSQDMAEDRR SLLHLSSRLN
GALRQEQNFA DRFLPDDEAA QALGKTCWEA LVSPVVQNIT SPDEDGISPL GWLLDQYLEC QEAVFNPQSR GPAFFSRVRR
LTHLLVLEHH HHHH