Recombinant CTDS1 protein (His tag)

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Recombinant Human CTDSP1 Fragment (residues 76-261), encompassing the FCP1 homology domain, is a high-purity protein designed for studying the specific dephosphorylation activity on RNA polymerase II's C-terminal domain, particularly at Ser-5 residues. This fragment serves as an essential tool for investigating transcriptional regulation mechanisms in neuronal and non-neuronal contexts.

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) is a nuclear enzyme that preferentially dephosphorylates 'Ser-5' within the tandem repeats of the RNA polymerase II subunit POLR2A's C-terminal domain. By controlling the phosphorylation state of POLR2A, CTDSP1 negatively regulates transcription, potentially influencing the transition from transcription initiation to elongation. It is recruited by the REST complex to silence neuronal genes in non-neuronal cells, highlighting its role in cell-type-specific gene expression. The protein localizes to the nucleus and colocalizes with RNA polymerase II, underscoring its direct involvement in transcriptional machinery.