Recombinant CSF1R protein (His tag)

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Introducing the recombinant human Macrophage colony-stimulating factor 1 receptor (CSF-1R) fragment (amino acids 20-517), a meticulously engineered protein encompassing all five Ig-like C2-type domains. This high-purity fragment serves as an essential tool for investigating receptor-ligand interactions, immune cell regulation, and signaling pathways in macrophage and monocyte biology.

The full-length CSF-1 receptor (CD115) is a crucial tyrosine-protein kinase cell-surface receptor that binds CSF1 and IL34, playing fundamental roles in hematopoietic cell survival, proliferation, and differentiation. It regulates innate immunity, inflammatory responses, bone resorption through osteoclast regulation, and reproductive system development. CSF-1R activates multiple signaling pathways including ERK1/2, JNK, AKT1, and STAT family members, while also influencing actin cytoskeleton reorganization and cell migration. Located as a single-pass type I membrane protein, its dysfunction impacts microglia development, cancer invasion, and inflammatory processes, making it a significant target for immunological and oncological research.