Recombinant CREB1 protein (His tag)

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Introducing the recombinant CREB-1 (208-327) fragment, a highly specific 120-amino acid protein derived from human Cyclic AMP-responsive element-binding protein 1. This fragment fully encompasses the critical bZIP domain, making it an ideal tool for researchers studying transcription factor mechanisms, DNA binding interactions, and cAMP-responsive signaling pathways.

CREB-1 is a phosphorylation-dependent transcription factor that stimulates transcription by binding to cAMP response elements (CRE) present in numerous viral and cellular promoters. Its transcriptional activity is enhanced by TORC coactivators and it plays crucial roles in circadian rhythm synchronization, adipose cell differentiation, and regulation of apoptotic and inflammatory responses in cardiomyocytes through ERFE-mediated AKT signaling. The protein is primarily localized to the nucleus, where it exerts its transcriptional regulatory functions. The bZIP domain contained within this fragment is essential for DNA binding and dimerization, making this recombinant protein particularly valuable for structural and functional studies of CREB-1's core DNA-binding capabilities.