Recombinant CPEB4 protein (His tag)

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Recombinant Human CPEB4 Fragment (467-729) is a high-purity protein product encompassing the two RNA recognition motifs (RRM 1 and RRM 2) of Cytoplasmic Polyadenylation Element-Binding Protein 4. This fragment is an essential tool for investigating sequence-specific RNA binding, conformational changes, and the regulation of mRNA translation in cellular processes such as the unfolded protein response and cell cycle progression.

Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is a sequence-specific RNA-binding protein that recognizes the uridine-rich cytoplasmic polyadenylation element (CPE) within mRNA 3'-UTRs. Upon RNA binding, it undergoes a significant conformational change. CPEB4 plays a critical role in cellular adaptation to endoplasmic reticulum stress by maintaining the translation of specific mRNAs when global protein synthesis is inhibited. It is also essential for cell cycle progression, particularly in cytokinesis and chromosomal segregation, and functions as an oncogene by promoting tumor growth through the regulation of factors like t-plasminogen activator. The protein is localized to the cytoplasm, endoplasmic reticulum, perinuclear region, and various neuronal projections, including dendrites, dendritic spines, and axons. Unlike CPEB1 and CPEB3, it is not involved in synaptic plasticity or learning and memory.