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Human CIRBP / Cold-inducible RNA-binding Protein (His Tag)

Cat.#: 502184

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Product Information

  • Product Name
    Human CIRBP / Cold-inducible RNA-binding Protein (His Tag)
  • Documents
  • Description
    Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
  • Protein name
    Cold-inducible RNA-binding protein
  • Protein short names
    CIRP; A18 HNRNP; GLYCINE-RICH RNA-BINDING PROTEIN CIRP; CIRBP; GLYCINE-RICH RNA BINDING PROTEIN; R74941; COLD INDUCIBLE RNA BINDING PROTEIN
  • Uniprot ID
    Q14011
  • Gene Name
    CIRBP; A18HNRNP; CIRP
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CIRBP (Q14011) (Met1-Glu172) was expressed with a polyhistide tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CIRBP consists of 187 amino acids and predicts a molecular mass of 20.5 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human CIRBP / Cold-inducible RNA-binding Protein (His Tag) SDS-PAGE

    Human CIRBP / Cold-inducible RNA-binding Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"