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Recombinant CNTFR protein (His tag)

Recombinant CNTFR protein (His tag)

Cat.#: 539877

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Product Information

  • Product Name
    Recombinant CNTFR protein (His tag)
  • Documents
  • Description

    Recombinant Human Ciliary Neurotrophic Factor Receptor Subunit Alpha (CNTFR-alpha) Fragment (residues 23-307) is a high-purity protein designed for studying receptor-ligand interactions and neurotrophic signaling pathways. This fragment encompasses key functional domains, making it an ideal tool for investigating CNTF receptor specificity and related cytokine signaling mechanisms.

    Ciliary Neurotrophic Factor Receptor Subunit Alpha (CNTFR-alpha) is a GPI-anchored cell membrane protein that serves as the specificity-determining subunit for CNTF binding. It functions as a receptor for the heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1, and also acts as part of a complex receptor for the neuroprotective peptide humanin in conjunction with IL6ST/GP130 and IL27RA/WSX1. The protein plays crucial roles in neurotrophic signaling and cellular protection pathways, with its membrane localization facilitating ligand recognition and signal initiation.

  • Protein name
    Ciliary neurotrophic factor receptor subunit alpha
  • Uniprot ID
    P26992
  • Gene Name
    CNTFR
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 23-307 aa (P26992) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 33.97 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 34 kDa band.
  • Purity
    >87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"