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Product Name
Recombinant CNOT8 protein (His tag)
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Description
Recombinant Human CNOT8 (CCR4-NOT transcription complex subunit 8) fragment (amino acids 1-292) is a high-quality protein product designed for structural and biochemical studies. This fragment, computationally optimized for stability and solubility, retains key functional domains and is ideal for investigating mRNA degradation, miRNA-mediated repression, and transcriptional regulation mechanisms.
The full-length CNOT8 protein, encoded by the CNOT8 gene in Homo sapiens, functions as a 3'-5' poly(A) exoribonuclease and is a catalytic component of the CCR4-NOT complex. This complex is integral to multiple cellular processes, including bulk mRNA degradation, miRNA-mediated repression, translational repression during initiation, and general transcription regulation. CNOT8 associates with BTG family proteins like TOB1 and BTG2, supporting their anti-proliferative roles. It localizes to both the cytoplasm and nucleus, reflecting its broad regulatory impact on gene expression and cellular homeostasis.
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Protein name
CCR4-NOT transcription complex subunit 8
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Uniprot ID
Q9UFF9
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Gene Name
CNOT8; CALIF; POP2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-292 aa (Q9UFF9) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 35.20 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 37 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"