CNGA4 Polyclonal Antibody

Cat.#: 162229

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Product Information

  • Product Name
    CNGA4 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to CNGA4
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse
  • Alternative names
    CNGA4 antibody; CNCA2 antibody; CNG-4 antibody; CNG4 antibody; CNG5 antibody; CNGB2 antibody; OCNC2 antibody; OCNCBETA antibody; OCNCb antibody; cyclic nucleotide gated channel alpha 4 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
  • Validations

    Western blot - CNGA4 Polyclonal Antibody

    Western blot - CNGA4 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using CNGA4 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit .Exposure time: 90s.

  • Background
    Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"