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Product Name
Recombinant CKS1 protein (His tag)
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Description
Recombinant Cyclin-dependent kinases regulatory subunit (CKS-1) fragment (residues 1-94), derived from Caenorhabditis elegans, offers a stable and soluble unit ideal for structural and biochemical studies. This fragment captures the essential domain involved in binding catalytic subunits of cyclin-dependent kinases, facilitating research into cell cycle regulation and mitotic exit mechanisms.
The full-length Cyclin-dependent kinases regulatory subunit (CKS-1) binds to the catalytic subunit of cyclin-dependent kinases and is essential for their biological function. It plays a critical role in the exit from M phase during early mitotic cell division, primarily by promoting the degradation of B-type cyclins, which leads to nuclear envelope breakdown and mitotic exit. This protein is localized in the nucleus, underscoring its involvement in key nuclear events during cell division, as supported by studies referenced in PubMed:11102813 and PubMed:16343905.
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Protein name
Cyclin-dependent kinases regulatory subunit
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Uniprot ID
Q17868
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Gene Name
cks-1; dom-6
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-94 aa (Q17868) were fused with 6His tag.
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 12.60 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 13 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"