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Product Name
Recombinant CKAP4 protein (His tag)
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Description
Recombinant Human CKAP4 (128-602) is a high-purity protein fragment derived from Cytoskeleton-associated protein 4 (Climp-63), designed for structural and biochemical studies. This 475-amino acid fragment offers a stable, soluble unit ideal for investigating endoplasmic reticulum-microtubule anchoring and antiproliferative signaling pathways.
Cytoskeleton-associated protein 4 (CKAP4), also known as Climp-63 or p63, is a multifunctional protein in Homo sapiens that anchors the endoplasmic reticulum to microtubules, maintaining cellular architecture. It also serves as a high-affinity cell surface receptor for the antiproliferative factor (APF), mediating its signaling to inhibit cell proliferation. Localized to the endoplasmic reticulum and cell membranes as a single-pass type II membrane protein, CKAP4 translocates to the perinuclear region upon APF stimulation, highlighting its dynamic role in cellular regulation and potential relevance in disease research.
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Protein name
Cytoskeleton-associated protein 4
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Uniprot ID
Q07065
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Gene Name
CKAP4
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 128-602 aa (Q07065) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 55.34 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 65 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"