Recombinant CHK1 protein (His tag)

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Recombinant Serine/threonine-protein kinase chk-1 (EC 2.7.11.1) fragment (amino acids 1-294) from Caenorhabditis elegans, encompassing the complete protein kinase domain. This high-quality recombinant protein serves as an essential tool for studying DNA damage response mechanisms, cell cycle regulation, and checkpoint control pathways in research applications.

Serine/threonine-protein kinase chk-1 is a critical regulatory enzyme required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to DNA damage or unreplicated DNA. The protein plays a vital role in germline cell cycle regulation and is essential for embryogenesis. Research demonstrates its function in delaying cell-cycle reentry of primordial germ cells following transcription-induced DNA damage. Chk-1 exhibits dynamic subcellular localization, primarily found in the cytoplasm with perinuclear accumulation and nuclear presence. The phosphorylated form specifically colocalizes with P granules in germline precursor cells, highlighting its importance in developmental processes and DNA damage response pathways.

1-294