Recombinant CENPA protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human CENPA (Centromere Protein A) Fragment (residues 45-140) is a high-purity, stable protein designed for structural and biochemical studies. This 96-amino acid fragment, derived from the essential centromeric histone variant CENPA, offers a soluble and functional unit ideal for investigating centromere-specific nucleosome assembly and kinetochore regulation.

Histone H3-like centromeric protein A (CENPA) is a specialized nucleosomal protein that replaces conventional histone H3 in centromeric chromatin, serving as a key epigenetic marker for centromere identity propagation through cell division. It localizes exclusively to centromeres and is critical for recruiting kinetochore proteins, facilitating proper chromosome segregation, mitosis progression, and cytokinesis. The full-length protein subtly alters nucleosome structure, resulting in less rigid DNA wrapping, which supports inner kinetochore assembly and ensures genomic stability. This fragment represents a stable, soluble region optimized for experimental applications, enabling focused studies on CENPA's role in centromere function without domain-specific constraints.