Recombinant CEGT protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Ceramide Glucosyltransferase (UGCG) Fragment (residues 216-287) is a highly purified, stable protein fragment designed for structural and biochemical studies. This 72-amino acid segment, derived from the key enzyme in glycosphingolipid synthesis, offers a soluble and functional unit ideal for investigating enzyme mechanisms, inhibitor screening, and molecular interactions.

Ceramide glucosyltransferase (EC 2.4.1.80), encoded by the UGCG gene, catalyzes the initial and rate-limiting step in glycosphingolipid (GSL) biosynthesis by transferring glucose from UDP-glucose to ceramide, forming glucosylceramide. This enzyme also demonstrates activity with UDP-xylose to produce xylosylceramide. GSLs are essential amphipathic components of membrane microdomains that mediate critical cellular processes including membrane trafficking, signal transduction, neural development, skin barrier formation, and nutritional lipid uptake. The full-length protein localizes to the Golgi apparatus membrane as a multi-pass membrane protein, where it initiates the synthesis of glucosylceramide-based GSLs that play fundamental roles in cell growth, differentiation, migration, and cell-to-cell interactions.