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Product Name
Recombinant CEAM6 protein (His tag)
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Description
Recombinant Human CEACAM6 Fragment (aa 35-320) is a high-purity protein designed for studying cell adhesion mechanisms and tumor progression. This fragment encompasses the complete Ig-like V-type and C2-type domains, making it an ideal tool for investigating homophilic and heterophilic interactions in cellular adhesion research.
CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6) is a cell surface glycoprotein that mediates calcium- and fibronectin-independent intercellular adhesion through homophilic interactions with itself and heterophilic interactions with other CEACAM family members like CEACAM5 and CEACAM8. It plays significant roles in neutrophil adhesion to activated endothelial cells, cell migration, and tumor progression. The protein is anchored to the apical cell membrane via a GPI-anchor and localizes to the cell surface glycocalyx, where it facilitates critical cell-cell adhesion events in both physiological and pathological contexts.
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Protein name
Cell adhesion molecule CEACAM6
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Uniprot ID
P40199
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Gene Name
CEACAM6; NCA
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 35-320 aa (P40199) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 32.91 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 33 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"