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Human ORP150/HYOU1/HSP12A (Grp170) (His Tag) recombinant protein

Cat.#: 501901

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Product Information

  • Product Name
    Human ORP150/HYOU1/HSP12A (Grp170) (His Tag) recombinant protein
  • Documents
  • Description
    Hypoxia up-regulated protein 1, also known as 150 kDa oxygen-regulated protein, 170 kDa glucose-regulated protein, ORP-150, GRP-170 and HYOU1, is a member of the heat shock protein 70 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1 (ORP150), HSPC1 (HSP86), HSPA5 (Bip), HSPD1 (HSP60), and several isoforms of the two testis-specific HSP70 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. It is highly expressed in liver and pancreas. HYOU1 is also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. HYOU1 has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. It may play a role as a molecular chaperone and participate in protein folding. Suppression of HYOU1 is associated with accelerated apoptosis. It is suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness.
  • Protein name
    cDNA FLJ45395 fis, clone BRHIP3027191, highly similar to 150 kDa oxygen-regulated protein (Orp150)
  • Protein short names
    ORP150; ORP-150; GRP170; CAB140; FLJ97572; GRP-170; AI415631; HSP12A; HYOU1; CBP-140; DKFZP686N08236; FLJ94899
  • Uniprot ID
    Q9Y4L1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the C-terminal segment of human HSP12A (NP_001124463.1) (Met 695-Leu 994) was expressed, fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human HSP12A consists of 311 amino acids and predictes a molecular mass of 35.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh HSP12A is approximately 55-65 kDa due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Validations

    Human ORP150 / HYOU1 / HSP12A Protein (His Tag) SDS-PAGE

    Human ORP150 / HYOU1 / HSP12A Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"