Recombinant CDK6 protein (His tag)

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Recombinant Human Cyclin-dependent kinase 6 (CDK6) Fragment (aa 1-326) is a high-purity protein encompassing the complete protein kinase domain. This fragment serves as an essential tool for studying G1/S cell cycle transition, differentiation processes, and kinase activity in various research applications.

Cyclin-dependent kinase 6 (CDK6) is a crucial serine/threonine-protein kinase (EC 2.7.11.22) that regulates cell cycle progression by promoting G1/S transition through phosphorylation of key substrates including pRB/RB1 and NPM1. CDK6 forms complexes with D-type cyclins to control cell cycle entry and plays dual roles in both preventing and promoting cell differentiation depending on cellular context. It is particularly important for proliferation of erythroid, hematopoietic, and pancreatic beta-cells, and contributes to neurogenesis in the hippocampus. The protein localizes to both cytoplasm and nucleus, with kinase activity primarily nuclear, and shows dynamic localization to the centrosome during mitosis and to membrane ruffles during cell spreading. The recombinant fragment (aa 1-326) contains the complete protein kinase domain, making it ideal for investigating CDK6's catalytic functions and regulatory mechanisms.