Recombinant CDK13 protein (His tag)

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Introducing the recombinant Cyclin-dependent kinase 13 (CDK13) fragment (residues 697-1031), a high-purity protein designed for studying kinase activity and RNA splicing mechanisms. This fragment encompasses the essential protein kinase domain, offering researchers a targeted tool for investigating CTD phosphorylation, transcription elongation, and splicing regulation in a simplified experimental context.

Cyclin-dependent kinase 13 (CDK13) is a key regulatory enzyme in human cells, primarily localized to nuclear speckles. It functions as a CTD kinase by hyperphosphorylating the RNA polymerase II C-terminal domain, playing a critical role in transcription elongation. CDK13 is also essential for RNA splicing, likely through phosphorylation of splicing factors such as SRSF1/SF2, and contributes to hematopoiesis. Notably, it interacts with acetylated HIV-1 Tat protein to enhance viral mRNA splicing, highlighting its significance in both cellular and viral processes. The full-length protein's activities make it a valuable subject for research in transcription regulation and RNA processing.