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Recombinant CD86 protein (His tag)

Recombinant CD86 protein (His tag)

Cat.#: 539953

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Special Price 294.7 USD

Availability: 3-4 weeks
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Product Information

  • Product Name
    Recombinant CD86 protein (His tag)
  • Documents
  • Description

    Recombinant Human CD86 (T-lymphocyte activation antigen CD86) Fragment (aa 24-247) is a high-purity protein designed to encompass the Ig-like V-type and Ig-like C2-type domains, providing an essential tool for studying T-cell activation, costimulatory signaling, and immune regulation mechanisms.

    The full-length CD86 protein is a single-pass type I membrane protein expressed on the cell surface, functioning as a critical receptor in the costimulatory signal required for T-lymphocyte proliferation and interleukin-2 production. It binds to CD28 or CTLA-4 to influence early T-cell activation decisions, such as immunity versus anergy, and regulates B-cell function and IgG(1) production. CD86 also activates the NF-kappa-B signaling pathway upon CD40 engagement and serves as a receptor for adenovirus subgroup B. Isoform 2 acts as a negative regulator of T-cell activation by interfering with CD86 cluster formation.

  • Protein name
    T-lymphocyte activation antigen CD86
  • Uniprot ID
    P42081
  • Gene Name
    CD86; CD28LG2
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 24-247 aa (P42081) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 27.20 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 27 kDa band.
  • Purity
    >90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"