Recombinant CD83 protein (His tag)

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Recombinant Human CD83 (hCD83) Fragment (aa 20-144) is a high-purity protein designed for immunological research. This fragment includes the complete Ig-like V-type domain, making it an ideal tool for studying CD83-mediated immune regulation, T-cell selection, and antigen presentation pathways in a controlled experimental setting.

CD83 is a transmembrane glycoprotein predominantly expressed on immune cells such as dendritic cells and lymphocytes, where it plays critical roles in regulating immune responses. It is essential for CD4+ T-cell selection, differentiation, and stability by modulating the E3 ubiquitin ligase MARCHF8, which controls MHCII trafficking. Additionally, CD83 inhibits MARCHF1-mediated ubiquitination and degradation of MHCII and CD86, thereby supporting antigen presentation and co-stimulatory signaling. As a single-pass type I membrane protein, CD83 functions at the cell surface to orchestrate protective immune responses against infections, highlighting its importance in both innate and adaptive immunity.