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Product Name
Cynomolgus CD83 (Fc Tag) recombinant protein
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Description
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD83 is considered as a marker of mature dendritic cells as well as an adhesion receptor that binds to resting monocytes and a subset of activated CD8+ T cells. In certain conditions, CD83 tended to dimerize or even multimerize through its aberrant intermolecular disulfide bonds. The injection of CD83-Ig can significantly enhaunce the rate of tumor growth and inhibit the T cell growth.
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Protein name
CD83 antigen isoform a
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Protein short names
MGC130313; HB15; MGC130312; BL11; CD83
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Uniprot ID
F6WX37
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Gene Name
CD83
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus CD83 (F6WX37) (Met1-Ala143) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus CD83 is a disulfide-linked homodimer. The reduced monomer comprises 365 amino acids and has a calculated molecular mass of 41 KDa.The apparent molecular mass of the protein is approximately 45-55 and 34 KDa respectively in SDS-PAGE.
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Purity
(87.6+11.5) % as determined by SDS-PAGE
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Validations
Cynomolgus CD83 Protein (Fc Tag) SDS-PAGE
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