Recombinant CD79B protein (His tag)

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This product is a recombinant protein fragment of the human B-cell antigen receptor complex-associated protein beta chain (CD79B), spanning residues 45-159. It represents a stable, soluble unit ideal for structural studies and biochemical assays related to B-cell receptor signaling.

The full-length CD79B protein, also known as Ig-beta or CD79b, is a critical component of the B-cell antigen receptor (BCR) complex. It works in cooperation with CD79A to initiate the BCR signal transduction cascade, which triggers internalization of the complex, trafficking to late endosomes, and antigen presentation. CD79B enhances phosphorylation of CD79A, potentially by recruiting kinases or protective binding partners, thereby sustaining signal propagation. It is localized to the cell membrane as a single-pass type I membrane protein and, following antigen binding, may translocate to lipid rafts, although signaling can also occur outside these microdomains. This makes CD79B essential for understanding B-cell activation and immune responses.