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Product Name
Recombinant CD70 protein (His tag)
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Description
Recombinant Human CD70 Antigen (Fragment 39-193) is a high-purity protein fragment designed for studying the TNF homology domain (THD) of CD70. This product enables researchers to investigate T cell activation and immune surveillance mechanisms mediated by the CD70-CD27 signaling pathway.
CD70 antigen, also known as CD27 ligand or tumor necrosis factor ligand superfamily member 7, is a type II transmembrane protein expressed on the plasma membrane of B cells. As the ligand for CD27 receptor on T cells, CD70 plays a crucial role in antigen-specific T cell activation and expansion. The CD70-CD27 signaling pathway provides essential immune surveillance of B cells, making it a key component in adaptive immune responses. The full-length protein is located in the cell membrane and functions through its extracellular domain to mediate T cell-B cell interactions.
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Protein name
CD70 antigen
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Uniprot ID
P32970
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Gene Name
CD70; CD27L; CD27LG; TNFSF7
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 39-193 aa (P32970) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 18.79 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 19 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"