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Product Name
Recombinant CD7 protein (His tag)
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Description
Recombinant Human CD7 Protein Fragment (26-135) is a high-purity, functional fragment encompassing the Ig-like domain of T-cell antigen CD7. This product is specifically designed for investigating CD7-mediated costimulatory signaling in T-cell and NK-cell activation, cytokine production, and immune response studies.
CD7 is a transmembrane glycoprotein expressed on T-cells and natural killer (NK) cells, playing a critical costimulatory role in immune activation. Upon binding to its ligand K12/SECTM1, CD7 enhances T-cell activation and promotes cytokine production, including IL-2. In resting NK-cells, CD7 activation significantly induces interferon-gamma levels, underscoring its importance in innate and adaptive immunity. As a single-pass type I membrane protein, CD7 is localized to the cell membrane, where it facilitates key signaling events in immune cell function and regulation.
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Protein name
T-cell antigen CD7
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Uniprot ID
P09564
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Gene Name
CD7
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 26-135 aa (P09564) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 13.68 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"