Recombinant CD68 protein (His tag)

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Recombinant Human Macrosialin (CD68) Fragment (aa 142-319) is a high-purity, soluble protein designed for structural and biochemical research. This 178-amino acid fragment represents a stable and functional unit of the full-length protein, ideal for investigating macrophage-specific activities such as phagocytosis and cellular interactions.

Macrosialin, also known as CD68, is a macrophage-specific glycoprotein implicated in phagocytic functions, including intracellular lysosomal metabolism and extracellular interactions with pathogens or other cells. It binds to tissue-specific lectins or selectins, facilitating macrophage homing to specific sites. The protein exhibits dynamic subcellular localization: the short isoform is primarily found on the cell membrane as a single-pass type I membrane protein, while the long isoform localizes to endosome and lysosome membranes. Rapid recycling of CD68 between these compartments may support macrophage mobility over selectin-bearing surfaces, underscoring its role in immune surveillance and response.