Recombinant CD59 protein (His tag)

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Recombinant CD59 glycoprotein fragment (amino acids 26-102) is a highly stable and soluble protein unit designed for structural and biochemical research. This fragment retains key functional domains essential for studying the protein's role as a potent inhibitor of the complement membrane attack complex (MAC), offering researchers a reliable tool for investigating immune regulation and cellular protection mechanisms.

CD59 glycoprotein, also known as Protectin or Membrane Inhibitor of Reactive Lysis (MIRL), is a critical human immune regulator that functions as a potent inhibitor of the complement membrane attack complex (MAC). It localizes to the cell membrane via a GPI-anchor, where it binds to C8 components during MAC assembly, preventing incorporation of C9 and formation of the osmolytic pore. This protective mechanism shields human cells from complement-mediated damage during immune activation. While the full-length protein is membrane-anchored, soluble forms have been identified in various tissues, though with reduced membrane-targeting capacity. The selected fragment (26-102) encompasses the core functional domain, enabling detailed study of CD59's molecular interactions without membrane association complexities.