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Product Name
Recombinant CD48 protein (His tag)
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Description
Recombinant Human CD48 (SLAMF2) Fragment (aa 27-220) is a high-purity protein designed for immunological research, encompassing the complete Ig-like C2-type domains essential for mediating immune cell activation and signaling through interactions with CD244/2B4 and CD2 receptors.
CD48 is a GPI-anchored cell surface glycoprotein that plays a critical role in immune regulation by interacting with receptors such as CD244/2B4 and CD2. These interactions facilitate T-cell signaling by recruiting Src family kinase LCK and LAT to the TCR/CD3 complex, promoting phosphorylation events and immunological synapse formation. CD48 also triggers cytotoxic granule release in T-lymphocytes and NK-cells via CD244 phosphorylation. It localizes to the cell membrane via GPI-anchoring, membrane rafts, and can also be found in secreted forms, highlighting its dynamic involvement in immune responses.
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Protein name
CD48 antigen
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Uniprot ID
P09326
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Gene Name
CD48; BCM1; BLAST1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 27-220 aa (P09326) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 24.00 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 24 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"