Recombinant CD3G protein (His tag)

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Recombinant Human CD3G (T-cell surface glycoprotein CD3 gamma chain) Fragment (aa 23-116) is a high-purity protein designed for immunological research. This 94-amino acid fragment encompasses the Ig-like domain, making it an ideal tool for studying domain-specific functions in T-cell receptor signaling and immune regulation.

The CD3 gamma chain is an essential component of the TCR-CD3 complex on T-lymphocytes, playing a critical role in adaptive immune responses. It participates in signal transduction across the cell membrane following T-cell receptor activation, containing immunoreceptor tyrosine-based activation motifs (ITAMs) that become phosphorylated by Src family kinases. Additionally, CD3G regulates the dynamic cycling and surface expression of the TCR complex through its di-leucine-based sorting motif. As a single-pass type I membrane protein located in the cell membrane, CD3G contributes to both initial T-cell activation and long-term receptor maintenance.