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Product Name
Recombinant CD38 protein (His tag)
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Description
Recombinant human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) fragment (residues 43-300) is a stable, soluble protein unit ideal for investigating calcium-signaling mechanisms, second messenger synthesis, and enzymatic functions in metabolic and immunological research.
The full-length CD38 protein, encoded by the CD38 gene in Homo sapiens, is a multifunctional enzyme located on the cell surface as a single-pass type II membrane protein. It synthesizes cyclic ADP-ribose (cADPR), a key second messenger that regulates glucose-induced insulin secretion, and also produces nicotinate-adenine dinucleotide phosphate (NAADP+), a Ca²⁺ mobilizer, from substrates like 2'-phospho-cADPR and NADP+. Additionally, CD38 exhibits cADPR hydrolase activity, playing a critical role in calcium signaling pathways relevant to cellular metabolism and immune responses, as evidenced by its classification as a CD antigen.
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Protein name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
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Uniprot ID
P28907
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Gene Name
CD38
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 43-300 aa (P28907) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 31.53 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 32 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"