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Product Name
Recombinant CD2B2 protein (His tag)
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Description
Recombinant CD2 antigen cytoplasmic tail-binding protein 2 homolog (Protein hole-in-one) fragment from Drosophila melanogaster, encompassing amino acids 130-319. This fragment includes the complete GYF domain (residues 260-316), providing a targeted tool for investigating domain-specific functions in epithelial repair and transcriptional regulation.
The full-length CD2 antigen cytoplasmic tail-binding protein 2 homolog, encoded by the holn1 gene, is essential for embryonic epithelial tissue repair in Drosophila melanogaster. It functions downstream of the rl pathway to regulate transcription of Ddc and msn genes, facilitating wound healing independently of actomyosin cable assembly. The protein is localized to the nucleus, where it likely exerts its transcriptional regulatory roles. This recombinant fragment enables focused study of the GYF domain's contribution to these critical biological processes.
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Protein name
CD2 antigen cytoplasmic tail-binding protein 2 homolog
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Uniprot ID
Q9VKV5
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Gene Name
holn1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 130-319 aa (Q9VKV5) were fused with 6His tag.
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Protein Species
Drosophila melanogaster
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Molecular weight
Predictes a molecular mass of 23.53 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 25 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"