Recombinant CD276 protein (His tag)

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• Material Safety Data Sheets (MSDS)

Recombinant Human CD276 (4Ig-B7-H3) Fragment (aa 29-466) is a high-purity protein designed for immunology and oncology research. This fragment encompasses the complete extracellular Ig-like domains (V-type and C2-type), offering a valuable tool to investigate T-cell regulation, tumor immune evasion, and costimulatory signaling mechanisms.

CD276 (B7-H3) is a single-pass type I transmembrane protein that modulates T-cell-mediated immune responses. It plays dual roles in immunity: acting as a costimulatory molecule that can enhance cytotoxic T-cell induction and interferon-gamma production, while also conferring protection to tumor cells by inhibiting natural killer cell-mediated lysis. The protein is clinically significant as a detection marker for neuroblastoma and is implicated in transplant rejection, mucosal immunity, and fetal-maternal immunological tolerance. Its location on the cell membrane makes it accessible for receptor-ligand studies and therapeutic targeting.